Protein Modification Reagents
Medchemexpress LLC Methyltetrazine-PEG5-NHS ester | 1802907-92-1 | 97.0% | C24H31N5O9 | 50 MG
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This product is for research use only.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Purity of 97.0%
eMolecules 139115-89-2 | Ms-PEG4 | Broadpharm | MFCD22574814 | 228.260 | C7H16O6S | 98.000 | CS(=O)(=O)OCCOCCOCCO | 1g | 112541219
Ms-PEG4 | Broadpharm | 139115-89-2 | MFCD22574814 | 228.260 | C7H16O6S | 98.000 | CS(=O)(=O)OCCOCCOCCO | 1g | 112541219
Medchemexpress LLC Dnp-peg4-dbco | 2149585-17-9 | MFCD31654037 | 97.0% | C35H39N5O10 | 10MG
DNP-PEG4-DBCO is a PEG-based PROTAC linker and click-chemistry reagent that combines a dinitrophenyl (DNP) moiety with a dibenzocyclooctyne (DBCO) group. The DBCO enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, supporting efficient bioconjugation and PROTAC assembly.
- Contains DNP and DBCO functional groups for dual reactivity.
- Enables copper-free SPAAC click chemistry with azide partners.
- Suitable for PROTAC linker synthesis and bioconjugation workflows.
- High purity (97.0%) for reliable analytical and preparative use.
- Stable under recommended storage conditions for extended shelf life.
Medchemexpress LLC S-acetyl-dPEG8-NHS ester | 1070798-99-0 | MFCD11041104 | >97.0% | 597.7 g/mol | C25H43NO13S | 50 MG
dPEG8-SATA (S-acetyl-dPEG8-NHS ester) is a heterobifunctional polyethylene glycol reagent used to introduce a protected thiol group onto biomolecules via NHS-ester chemistry. The hydrophilic dPEG8 spacer provides defined spacing and aqueous solubility, while the SATA protecting group allows controlled deprotection to liberate a free thiol for downstream conjugation and crosslinking applications.
- Provides a protected thiol for controlled thiolation.
- Reacts via NHS-ester chemistry for efficient amine labeling.
- Hydrophilic spacer improves solubility in aqueous media.
- Defined spacer length reduces steric hindrance in conjugates.
- High purity suitable for bioconjugation workflows.
- Available in multiple pack sizes for laboratory use.
Medchemexpress LLC Tamra-PEG2-maleimide | 2304558-24-3 | MFCD31811449 | 95.0% | 640.68 g/mol | C35H36N4O8 | 5 MG
TAMRA-PEG2-Maleimide is a thiol-reactive fluorescent dye comprising a tetramethylrhodamine core connected via a PEG2 spacer to a maleimide moiety. It enables covalent labeling of cysteine residues for fluorescence-based assays, imaging, and bioconjugation workflows, and is supplied as a solid with specified purity and storage recommendations.
- Thiol-reactive maleimide group for selective cysteine labeling.
- Tetramethylrhodamine fluorophore for red fluorescence applications.
- PEG2 spacer improves solubility and reduces steric hindrance.
- High purity for consistent labeling performance.
- Soluble in DMSO; handle under low-light conditions.
- Suitable for protein, peptide, and biomolecule conjugation.
TARGETMOL CHEMICALS INC CL-C6-PEG4-O-CH2COOH 50MG
Also available in 5 mg 10 mg 100 mg and bulk. Please contact Fisher for quotes. Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is an effective pegylated PROTAC linker which is often used in PROTAC synthesis of chloroanes (HaloPROTACs). purity: 99%
![Medchemexpress LLC 4,7,10,13-tetraoxahexadecanediamide, N1,N16-bis[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl] | 2182601-68-7 | 97.4% | 810.93 | C48H50N4O8 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204012.png-250.jpg)
Medchemexpress LLC 4,7,10,13-tetraoxahexadecanediamide, N1,N16-bis[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl] | 2182601-68-7 | 97.4% | 810.93 | C48H50N4O8 | 25 MG
DBCO-PEG4-DBCO is a PEG-based bifunctional dibenzocyclooctyne (DBCO) linker that enables strain-promoted alkyne-azide cycloaddition (SPAAC) for copper-free click chemistry. It contains two DBCO groups connected by a PEG4 spacer, is supplied as a white-to-yellow solid, and is used as a cleavable linker in ADC and PROTAC synthesis.
- enables copper-free SPAAC (strain-promoted alkyne-azide cycloaddition)
- contains two DBCO reactive groups connected by a PEG4 spacer
- high purity: 97.4% (HPLC)
- molecular weight: 810.93 g/mol
- supplied as a white-to-yellow solid with recommended sealed, moisture-free storage
Medchemexpress LLC DBCO-PEG6-NHS ester | 95.0% | 737.79 g·mol⁻¹ | C38H47N3O12 | 10 MG
DBCO-PEG6-NHS ester is a bifunctional click-chemistry reagent combining a dibenzocyclooctyne (DBCO) moiety and an N-hydroxysuccinimide (NHS) ester separated by a six-unit polyethylene glycol spacer. It is designed for amine-specific conjugation and copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized partners, and is supplied as a light yellow liquid.
- Bifunctional linker with DBCO and NHS ester groups.
- PEG6 spacer improves solubility and reduces steric hindrance.
- Reacts with primary amines for stable covalent attachment.
- Performs copper-free SPAAC with azide groups for bioorthogonal labeling.
- Purity approximately 95% as provided in product documentation.
- Store protected from light and under inert atmosphere; recommended low-temperature storage for long-term stability.
Medchemexpress LLC Propargyl-PEG6-N3 | 1198080-03-3 | 100 MG
Propargyl-PEG6-N3 is a PEG-based PROTAC linker employed in the synthesis of PROTACs. It functions as a versatile click chemistry reagent, featuring an Azide group. This group readily participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) when combined with molecules containing Alkyne groups. Furthermore, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules that possess DBCO or BCN groups, offering flexible synthetic pathways.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains an Azide group.
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with Alkyne groups.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
Medchemexpress LLC Dspe-peg-amine (ammonium) | 474922-26-4 | 98.8% | 1000 (average) | (C2H4O)nN2O10P·NH3 | 25 MG
DSPE-PEG-Amine (average MW 1000, ammonium salt) is a PEGylated phospholipid with a terminal primary amine used to functionalize liposomes and nanoparticles. The hydrophobic DSPE anchor incorporates into lipid bilayers while the PEG spacer presents a reactive amine at the particle surface for covalent conjugation to ligands, dyes, or biomolecules in delivery and surface-modification applications.
- PEGylated phospholipid with terminal primary amine.
- Average molecular weight approximately 1000 daltons.
- Ammonium salt form to aid handling and solubility.
- Enables covalent conjugation to NHS-esters, aldehydes, and other activated groups.
- Integrates into liposome bilayers for surface functionalization.
- Suitable for nanoparticle coating and targeted delivery research.
eMolecules 1263044-40-1 | Medchem Express | Biotin-PEG3-OH | 50mg | 781212818 | HY-135924 | 375.48 | C16H29N3O5S
AstaTech | 28-DICHLOROQUINOLINE-3-CARBOXALDEHYDE | 1g | 200610555 | 52861 | 97.000 | 144918-96-7 | MFCD06202349 | 226.060 | C10H5Cl2NO
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Broadpharm Iodoacetamido-PEG6-azide| 100mg| 1240737-77-2| Purity 98%
Iodoacetamido-PEG6-azide| 100mg| 1240737-77-2| Purity 98%
Medchemexpress LLC DSPE-PEG-FITC | 1000788-53-3 | 95.0% | 100 MG
DSPE-PEG-FITC is a fluorescein (FITC)-labeled PEGylated phospholipid (average molecular weight 1000) supplied as a yellow powder for research applications. It is used to introduce a green fluorescent label into liposomes, micelles, and other lipid-based nanoparticles for visualization and tracking in biological studies.
- Fluorescent tag for green fluorescence detection (FITC).
- PEGylated phospholipid for stable incorporation into lipid bilayers and micelles.
- Average molecular weight 1000 to define PEG chain length.
- Reagent grade purity, 95%.
- Supplied as a yellow powder with defined cold-storage recommendations.
- Intended for research use only.
Medchemexpress LLC Dde Biotin-PEG4-DBCO | 1807512-43-1 | 96.17% | C47H61N5O9S | 100 MG
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs consist of two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have azide groups
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins